Mery Carlos M, Lawrence Silvana M, Krishnamurthy Rajesh, Sexson-Tejtel S Kristen, Carberry Kathleen E, McKenzie E Dean, Fraser Charles D
Coronary Anomalies Program, Texas Children's Hospital, Houston, Texas; Michael E. DeBakey Department of Surgery, Texas Children's Hospital/Baylor College of Medicine, Houston, Texas.
Coronary Anomalies Program, Texas Children's Hospital, Houston, Texas; Division of Pediatric Cardiology, Texas Children's Hospital/Baylor College of Medicine, Houston, Texas.
Semin Thorac Cardiovasc Surg. 2014 Summer;26(2):110-22. doi: 10.1053/j.semtcvs.2014.08.001. Epub 2014 Aug 11.
Anomalous aortic origin of a coronary artery (AAOCA) is a congenital abnormality of the origin or course of a coronary artery that arises from the aorta. It is the second most common cause of sudden cardiac death in young athletes. Its exact prevalence, the pathophysiological mechanisms that cause sudden cardiac death, the actual risk of death for the different types of AAOCA, the optimal way to evaluate these patients, and whether any treatment strategies decrease the risk of sudden cardiac death in patients diagnosed with AAOCA are unknown. This article analyzes what is currently known and unknown about this disease. It also describes the creation of a dedicated multidisciplinary coronary anomalies program and the development of a framework in an initial attempt to standardize the evaluation and management of these patients.
冠状动脉异常起源于主动脉（AAOCA）是一种冠状动脉起源或走行的先天性异常，该冠状动脉发自主动脉。它是年轻运动员心源性猝死的第二大常见原因。其确切患病率、导致心源性猝死的病理生理机制、不同类型AAOCA的实际死亡风险、评估这些患者的最佳方法，以及任何治疗策略是否能降低被诊断为AAOCA患者的心源性猝死风险均尚不清楚。本文分析了目前关于这种疾病已知和未知的情况。它还描述了一个专门的多学科冠状动脉异常项目的创建，以及初步尝试制定一个框架以规范这些患者的评估和管理。
