Chaudhary Umair J, Duncan John S
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; MRI Unit, Epilepsy Society, Chesham Lane, Chalfont St Peter, Buckinghamshire SL9 0RJ, UK.
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK; MRI Unit, Epilepsy Society, Chesham Lane, Chalfont St Peter, Buckinghamshire SL9 0RJ, UK; Queen Square Division, UCLH NHS Foundation Trust, Queen Square, London WC1N 3BG, UK.
Neuroimaging Clin N Am. 2014 Nov;24(4):671-94. doi: 10.1016/j.nic.2014.07.001. Epub 2014 Nov 1.
The lifetime prevalence of epilepsy ranges from 2.7 to 12.4 per 1000 in Western countries. Around 30% of patients with epilepsy remain refractory to antiepileptic drugs and continue to have seizures. Noninvasive imaging techniques such as functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) have helped to better understand mechanisms of seizure generation and propagation, and to localize epileptic, eloquent, and cognitive networks. In this review, the clinical applications of fMRI and DTI are discussed, for mapping cognitive and epileptic networks and organization of white matter tracts in individuals with epilepsy.
在西方国家，癫痫的终生患病率为每1000人中有2.7至12.4例。约30%的癫痫患者对抗癫痫药物仍有耐药性，且持续发作。功能磁共振成像（fMRI）和扩散张量成像（DTI）等非侵入性成像技术有助于更好地理解癫痫发作的产生和传播机制，并对癫痫、明确的和认知网络进行定位。在本综述中，讨论了fMRI和DTI在绘制癫痫患者认知和癫痫网络以及白质束组织方面的临床应用。
