Oba Utako, Koga Yuhki, Hoshina Takayuki, Suminoe Aiko, Abe Kenji, Hayashida Makoto, Taguchi Tomoaki, Hara Toshiro
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J Infect Chemother. 2015 Apr;21(4):302-4. doi: 10.1016/j.jiac.2014.10.015. Epub 2014 Nov 11.
The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.
乙型肝炎病毒（HBV）的基因型具有独特的地理分布，其中HBV基因型H在包括日本在内的东亚地区非常罕见。我们在此报告一例患有肝细胞癌（HCC）的12岁日本女性病例，该患者表现为HBV基因型H。值得注意的是，从该患者分离出的HBV在前S2区域存在缺失突变。尚未对该HCC患者的HBV基因型H基因组进行详细分析。前S2区域的缺失突变可能在儿童肝癌发生中起重要作用，也可能出现在基因型H中。
