Instituto de Microbiología y Parasitología Médica, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.
J Viral Hepat. 2012 Nov;19(11):823-8. doi: 10.1111/j.1365-2893.2012.01620.x. Epub 2012 May 21.
Prevalence rates of hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) pre-S mutants among most genotypes are still lacking. In this study, viral (sub)genotypes of 70 Argentine nucleotide sequences (33 newly obtained) were determined by phylogenetic analysis, and the presence of such mutants was assessed in the American continent for the first time. Nucleotide substitutions of the pre-S2 start codon were observed in 10% of the HBV/A2 sequences. Ten per cent of the HBV/A2 and 12.5% of the HBV/F1b - but none of HBV/F4 - exhibited a deletion in the pre-S1/pre-S2 region. The contribution of these variants to liver cirrhosis (LC) and/or HCC development among HBV/F and HBV/A isolates deserves further prospective clinical studies.
在大多数基因型中，肝癌（HCC）相关乙型肝炎病毒（HBV）前 S 突变体的流行率仍然缺乏。在这项研究中，通过系统发生分析确定了 70 个阿根廷核苷酸序列（33 个新获得）的病毒（亚）基因型，并首次在美洲大陆评估了这些突变体的存在。在 HBV/A2 序列中观察到前 S2 起始密码子的核苷酸取代占 10%。10%的 HBV/A2 和 12.5%的 HBV/F1b - 但 HBV/F4 均没有 - 在 pre-S1/pre-S2 区域发生缺失。这些变异体在 HBV/F 和 HBV/A 分离株中导致肝硬化（LC）和/或 HCC 发展的贡献值得进一步进行前瞻性临床研究。
