Khan Z, Ahmad S, Al-Obaid K, Joseph L, Chandy R
Department of microbiology, faculty of medicine, Kuwait university, P.O. Box 24923, 1311 Safat, Kuwait.
Department of microbiology, faculty of medicine, Kuwait university, P.O. Box 24923, 1311 Safat, Kuwait.
J Mycol Med. 2015 Mar;25(1):71-5. doi: 10.1016/j.mycmed.2014.04.002. Epub 2014 Oct 22.
A rare case of bloodstream infection caused by Candida kefyr is described. The diagnosis was established by repeatedly isolating the yeast in blood cultures and by detecting C. kefyr-specific DNA in serum samples. Demonstration of elevated serum levels of β-D-glucan and Candida mannan also provided additional diagnostic evidence. The identity of the isolates was confirmed by PCR sequencing of the ITS region of rDNA. This is the first report of C. kefyr candidemia from Kuwait and the Middle East. The report highlights emerging clinical significance of rare Candida spp. in etiology of candidemia and reinforces the adjunctive role of biomarkers in diagnosis.
本文描述了一例由克菲假丝酵母菌引起的罕见血流感染病例。通过在血培养中反复分离出该酵母菌以及检测血清样本中克菲假丝酵母菌特异性DNA来确诊。血清β-D-葡聚糖和念珠菌甘露聚糖水平升高也提供了额外的诊断证据。通过对rDNA的ITS区域进行PCR测序确认了分离株的身份。这是科威特和中东地区首例关于克菲假丝酵母菌血症的报告。该报告强调了罕见念珠菌属在念珠菌血症病因中日益凸显的临床意义，并强化了生物标志物在诊断中的辅助作用。
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