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Effect of nedocromil sodium on down-regulation of pulmonary beta-adrenoceptors.

作者信息

Kioumis I, Ukena D, Barnes P J

机构信息

Department of Thoracic Medicine, National Heart and Lung Institute, London.

出版信息

Clin Sci (Lond). 1989 Jun;76(6):599-602. doi: 10.1042/cs0760599.

DOI:10.1042/cs0760599
PMID:2544343
Abstract
  1. We have studied the effect of the anti-inflammatory anti-asthma drug, nedocromil sodium, on down-regulation of pulmonary beta-adrenoceptors in guinea-pig lung. 2. Incubation of minced lung with isoprenaline (10 mumol/l) resulted in a reduction in maximum binding capacity of [125I]iodocyanopindolol to lung membranes from 246 +/- 4 to 169 +/- 6 fmol/mg of protein (mean +/- SEM, P less than 0.01, n = 18). 3. Nedocromil sodium, which had no direct effect on [125I]iodocyanopindolol binding, prevented isoprenaline-induced down-regulation, giving complete protection at a dose of 100 mumol/l. 4. The mechanism of this effect is not certain, but nedocromil sodium may interfere with the internalization of beta-adrenoceptors in pulmonary parenchymal cells. This may have some therapeutic relevance.
摘要

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