[通过HRT-III、SD-OCT及新型彩色成像Laguna ONhE程序测量杯盘比的相关性研究]

[Correlating cup-to-disc ratios measured by HRT-III, SD-OCT and the new color imaging Laguna ONhE procedure].

作者信息

Rodríguez Uña I, Méndez Hernández C D, Sáenz-Francés F, García Feijóo J

机构信息

Servicio de Oftalmología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.

出版信息

Arch Soc Esp Oftalmol. 2015 May;90(5):212-9. doi: 10.1016/j.oftal.2014.09.007. Epub 2014 Nov 15.

DOI:10.1016/j.oftal.2014.09.007

PMID:25443462

Abstract

OBJECTIVE

To examine correlations between cup-to-disc (C/D) ratios determined by the new Laguna ONhE (optic nerve hemoglobin) color imaging procedure, spectral domain optical coherence tomography (OCT), confocal scanning laser tomography using Heidelberg retina tomography (HRT), and examining retinal images.

METHODS

C/D ratio measurements were made on 154 eyes of 154 subjects (52 healthy controls, 36 with ocular hypertension and 66 with primary open-angle glaucoma) using the Laguna ONhE, HRT-III (Heidelberg Engineering) and OCT Spectralis (Heidelberg Engineering) instruments and photographs of the optic disc were examined by a blinded observer (experienced glaucoma specialist).

RESULTS

Global intraclass correlation coefficients (ICC) were: 0.379 (95% CI: 0.233-0.508) for Laguna ONhE-HRT, 0.621 (95% CI: 0.513-0.709) for Laguna ONhE-OCT, and 0.558 (95% CI: 0.398-0.678) for the Laguna ONhE-observer, indicating significant agreement in each case (P<.001). The highest ICC was recorded for OCT- observer (0.715; 95% CI: 0.605-0.795).

CONCLUSIONS

C/D ratios measured using the Laguna ONhE procedure correlated well with OCT measurements and retinography measurements made by an experienced observer. Best correlation was observed for OCT versus observer measurements. Agreement was good between the Laguna ONhE, OCT and observer measurements, and was somewhat lower between HRT and the remaining procedures.

摘要

目的

研究采用新型Laguna ONhE（视神经血红蛋白）彩色成像程序、光谱域光学相干断层扫描（OCT）、使用海德堡视网膜断层扫描（HRT）的共焦扫描激光断层扫描以及检查视网膜图像所测定的杯盘（C/D）比之间的相关性。

方法

使用Laguna ONhE、HRT-III（海德堡工程公司）和OCT Spectralis（海德堡工程公司）仪器，对154名受试者的154只眼睛（52名健康对照者、36名高眼压症患者和66名原发性开角型青光眼患者）进行C/D比测量，并由一名不知情的观察者（经验丰富的青光眼专家）检查视盘照片。

结果

总体组内相关系数（ICC）分别为：Laguna ONhE-HRT为0.379（95%可信区间：0.233 - 0.508），Laguna ONhE-OCT为0.621（95%可信区间：0.513 - 0.709），Laguna ONhE-观察者为0.558（95%可信区间：0.398 - 0.678），表明每种情况下均有显著一致性（P<0.001）。OCT-观察者的ICC最高（0.715；95%可信区间：0.605 - 0.795）。