Altavista M C, Cassetta E, Brusa L, Viselli F, Denaro A, Ventriglia M, Pasqualetti P, Peppe A
U.O. Neurologia, ACO San Filippo Neri, Rome, Italy.
U.O. Neurologia, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy.
Parkinsonism Relat Disord. 2015 Feb;21(2):95-100. doi: 10.1016/j.parkreldis.2014.11.002. Epub 2014 Nov 14.
Verifying the validity and feasibility of the WOQ-19 as a useful tool in routine clinical practice and in management of patients.
532 consecutive Parkinson's disease (PD) patients were recruited from 6 different neurological outpatient units, specialized in movement disorders, of central Italy. Inclusion criteria were diagnosis of PD and any current pharmacological treatment of PD while exclusion criteria were evident cognitive or depressive impairment, infusion with dopamine agonists or Duodopa, or Deep Brain Stimulation therapy. Patients were asked to complete the Italian version of WOQ-19 before the neurological visit. A medical form for the collection of demographic and clinical data of patients and for the evaluation of comprehensibility and usability the WOQ-19 was filled by the neurologist during the visit.
Our data confirmed that WOQ-19 was able to identify WO in 69% of patients, a percentage similar to the recently reported in the Italian WOQ-19 validation study. Motor symptoms were more frequent than non-motor symptoms (80% vs. 20%). Patients who experienced WO had a higher age of PD onset, more severe disease, longer disease duration and were more likely to be female.
The WOQ-19 was understandable for the patient, easily administered and suitable for routine outpatient use. It could be also particularly useful in clinical practice in the early identification of non-motor symptoms, often under reported by patients and revealed only with clinical support.
验证WOQ - 19作为常规临床实践及患者管理中有用工具的有效性和可行性。
从意大利中部6个不同的专注于运动障碍的神经科门诊招募了532例连续的帕金森病（PD）患者。纳入标准为PD诊断及任何当前的PD药物治疗，排除标准为明显的认知或抑郁障碍、多巴胺激动剂或Duodopa输注、或深部脑刺激疗法。患者在神经科就诊前被要求完成意大利语版的WOQ - 19。神经科医生在就诊期间填写一份用于收集患者人口统计学和临床数据以及评估WOQ - 19可理解性和可用性的医疗表格。
我们的数据证实，WOQ - 19能够在69%的患者中识别出WO，这一百分比与意大利WOQ - 19验证研究中最近报道的相似。运动症状比非运动症状更常见（80%对20%）。经历WO的患者PD发病年龄更高、疾病更严重、病程更长且更可能为女性。
WOQ - 19对患者来说易于理解，易于实施且适合常规门诊使用。它在临床实践中对于早期识别非运动症状可能也特别有用，这些症状患者往往报告不足，只有在临床支持下才能发现。
