Ho A K, Chik C L, Klein D C
Section on Neuroendocrinology, National Institute of Child Health and Human Development, Bethesda, MD 20892.
FEBS Lett. 1989 Jun 5;249(2):207-12. doi: 10.1016/0014-5793(89)80625-8.
The effect of forskolin on cGMP regulation was investigated using dispersed rat pinealocytes. Forskolin stimulated cGMP accumulation in a concentration-dependent manner; this response was strongly potentiated by an alpha 1-adrenergic----[Ca2+]i mechanism involving protein kinase C. These findings provide further evidence that activation of two receptor-regulated signal transduction mechanisms may be commonly required for maximal stimulation of cGMP accumulation, and establish a new experimental approach to the study of cGMP regulation.
使用分散的大鼠松果体细胞研究了福斯高林对环磷酸鸟苷（cGMP）调节的影响。福斯高林以浓度依赖的方式刺激cGMP积累；这种反应通过涉及蛋白激酶C的α1 - 肾上腺素能----[钙离子]i机制得到强烈增强。这些发现进一步证明，最大程度刺激cGMP积累可能通常需要激活两种受体调节的信号转导机制，并建立了一种研究cGMP调节的新实验方法。
