血脑屏障功能障碍、癫痫发作与癫痫

Blood-brain barrier dysfunction, seizures and epilepsy.

作者信息

van Vliet E A, Aronica E, Gorter J A

机构信息

Academic Medical Center, Department (Neuro)Pathology, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Semin Cell Dev Biol. 2015 Feb;38:26-34. doi: 10.1016/j.semcdb.2014.10.003. Epub 2014 Nov 6.

DOI:10.1016/j.semcdb.2014.10.003

PMID:25444846

Abstract

The blood-brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain, which is essential for normal neuronal functioning. BBB function is impaired in several neurological diseases, including epilepsy in which it may lead to abnormal and excessive neuronal firing. In this review we will discuss how BBB dysfunction can affect neuronal function and how this can lead to seizures and epilepsy. We will also summarize new therapies that aim to preserve or restore BBB function in order to prevent or reduce epileptogenesis.

摘要

血脑屏障（BBB）是一个将大脑与血液分隔开的动态复杂系统。它有助于维持大脑的内环境稳定，这对神经元的正常功能至关重要。在包括癫痫在内的几种神经系统疾病中，血脑屏障功能会受损，在癫痫中血脑屏障功能受损可能导致神经元异常过度放电。在这篇综述中，我们将讨论血脑屏障功能障碍如何影响神经元功能，以及这如何导致癫痫发作和癫痫。我们还将总结旨在维持或恢复血脑屏障功能以预防或减少癫痫发生的新疗法。