Macaskill Anne C, Harrow Catherine C, Harper David N
Victoria University of Wellington, School of Psychology, PO Box 600, Wellington, New Zealand.
Victoria University of Wellington, School of Psychology, PO Box 600, Wellington, New Zealand.
Pharmacol Biochem Behav. 2015 Jan;128:62-7. doi: 10.1016/j.pbb.2014.11.009. Epub 2014 Nov 13.
Different drugs produce different patterns of impairment on delayed matching-to-sample tasks. For example, (+/-)3,4-methylenedioxymethamphetamine (MDMA) produces an increase in proactive interference. That is, subjects are less accurate when they are required to make a response different to the one they made on the immediately previous trial. The current study assessed whether methamphetamine also produces this particular pattern of disruption in delayed matching-to-sample performance in rats. Methamphetamine primarily reduced accuracy on trials where the correct response differed from the one made on the previous trial. Thus methamphetamine, like MDMA and other stimulant-based drugs of abuse, increased proactive interference. This impairment was reduced by prior administration of the dopamine D1 antagonist SCH23390. These results further extend a general conclusion that a range of stimulant-based drugs may disrupt working memory function indirectly via a tendency to repeat previously made responses and that this disruption is related to D1 receptor activity.
不同药物对延迟匹配样本任务产生不同的损伤模式。例如，（±）3,4-亚甲基二氧甲基苯丙胺（摇头丸）会增加前摄干扰。也就是说，当要求受试者做出与前一次试验不同的反应时，他们的准确性会降低。当前研究评估了甲基苯丙胺是否也会在大鼠的延迟匹配样本任务表现中产生这种特定的干扰模式。甲基苯丙胺主要降低了正确反应与前一次试验不同的试验的准确性。因此，甲基苯丙胺与摇头丸及其他基于兴奋剂的滥用药物一样，增加了前摄干扰。预先给予多巴胺D1拮抗剂SCH23390可减轻这种损伤。这些结果进一步扩展了一个普遍结论，即一系列基于兴奋剂的药物可能通过重复先前做出的反应的倾向间接破坏工作记忆功能，并且这种破坏与D1受体活性有关。
