Róg Tomasz, Vattulainen Ilpo
Department of Physics, Tampere University of Technology, Tampere, Finland.
Department of Physics, Tampere University of Technology, Tampere, Finland; MEMPHYS-Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark.
Chem Phys Lipids. 2014 Dec;184:82-104. doi: 10.1016/j.chemphyslip.2014.10.004. Epub 2014 Nov 1.
Lipids rafts are considered to be functional nanoscale membrane domains enriched in cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell membranes. Lipids, together with membrane-associated proteins, are therefore considered to form nanoscale units with potential specific functions. Although the understanding of the structure of rafts in living cells is quite limited, the possible functions of rafts are widely discussed in the literature, highlighting their importance in cellular functions. In this review, we discuss the understanding of rafts that has emerged based on recent atomistic and coarse-grained molecular dynamics simulation studies on the key lipid raft components, which include cholesterol, sphingolipids, glycolipids, and the proteins interacting with these classes of lipids. The simulation results are compared to experiments when possible.
脂筏被认为是富含胆固醇和鞘脂的功能性纳米级膜结构域，尤其以细胞膜外小叶为特征。因此，脂质与膜相关蛋白一起被认为形成了具有潜在特定功能的纳米级单元。尽管对活细胞中脂筏结构的了解相当有限，但脂筏的可能功能在文献中得到了广泛讨论，突出了它们在细胞功能中的重要性。在这篇综述中，我们讨论了基于最近对关键脂筏成分（包括胆固醇、鞘脂、糖脂以及与这些类脂质相互作用的蛋白质）的原子和粗粒度分子动力学模拟研究而产生的对脂筏的理解。在可能的情况下，将模拟结果与实验进行了比较。
