Ben Abdallah Chabchoub R, Turki H, Mahfoudh A
Service pédiatrie, urgences et réanimation pédiatriques, CHU Hédi Chaker, Sfax, Tunisie.
Service de dermatologie, CHU Hédi Chaker, Sfax, Tunisie.
Arch Pediatr. 2014 Dec;21(12):1364-6. doi: 10.1016/j.arcped.2014.09.011. Epub 2014 Oct 27.
The association of chronic granulomatosis disease (CGD) with autoimmune diseases such as lupus has been described but remains rare. K… is a boy born of a consanguineous marriage. In the family history, two brothers had died at a young age. He had been followed up since the age of 6 months for CGD. At 11 years of age, he developed malar rash, cheilitis, oral ulceration, and photosensitivity. Systemic lupus erythematosus (SLE) was confirmed by the presence of high levels of antinuclear antibodies. This observation demonstrates that with the clinical association of recurrent infections and skin lesions the diagnosis of CGD with SLE must be considered.
慢性肉芽肿病（CGD）与狼疮等自身免疫性疾病的关联已有报道，但仍较为罕见。K……是一名近亲结婚所生的男孩。家族史中，有两个兄弟早亡。他自6个月大起就因CGD接受随访。11岁时，他出现了面颊部皮疹、唇炎、口腔溃疡和光敏性。抗核抗体水平升高确诊为系统性红斑狼疮（SLE）。该观察结果表明，对于反复感染和皮肤病变的临床关联情况，必须考虑CGD合并SLE的诊断。
