重度抑郁症和心境恶劣障碍患者注射人促肾上腺皮质激素释放激素后血浆中N-促肾上腺皮质激素原、促肾上腺皮质激素和皮质醇的变化
Plasma N-POMC, ACTH and cortisol following hCRH administration in major depression and dysthymia.
作者信息
Leake A, Griffiths H W, Ferrier I N
机构信息
MRC Neurochemical Pathology Unit, Newcastle General Hospital, U.K.
出版信息
J Affect Disord. 1989 Jul-Aug;17(1):57-64. doi: 10.1016/0165-0327(89)90024-4.
The concentrations of plasma N-terminal pro-opiomelanocortin, adrenocorticotropic hormone and cortisol in response to a 14:30 h human corticotrophin releasing hormone (hCRH) stimulation test (1 microgram/kg) were measured in control, major depression and dysthymic subjects. The increases in all three hormones were similar in the depressed groups when compared to the control values. The elevation in cortisol after hCRH was significantly greater in major depression when compared to the dysthymic subjects. The significance of these findings is discussed.
在对照组、重度抑郁症患者和心境恶劣障碍患者中，测量了在14:30进行的人促肾上腺皮质激素释放激素（hCRH）刺激试验（1微克/千克）后血浆N端前阿黑皮素原、促肾上腺皮质激素和皮质醇的浓度。与对照值相比，抑郁组中这三种激素的增加相似。与心境恶劣障碍患者相比，重度抑郁症患者在hCRH刺激后皮质醇的升高明显更大。对这些发现的意义进行了讨论。
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