He Ya-Cong, Zou Yike, Peng Cheng, Liu Jian-Lin, He Cheng-Jun, Guo Li, Xie Xiao-Fang, Xiong Liang
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China.
Department of Chemistry, University of Pennsylvania, 231 S. 34 Street, Philadelphia, PA 19104-6323, United States.
Fitoterapia. 2015 Jan;100:7-10. doi: 10.1016/j.fitote.2014.11.006. Epub 2014 Nov 15.
Two new 2,4'-epoxy-8,5'-neolignans (1 and 2), together with five known 7,9';7',9-diepoxylignans (3-7), were isolated from an ethyl acetate soluble portion of a hepatoprotective water decoction of Penthorum chinese. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. This is the second report of 2,4'-epoxy-8,5'-neolignans from plants. Compounds 2, 6, and 7 showed in vitro protective activities against acetaminophen-induced hepatocyte injury at 5 μM.
从赶黄草保肝水煎剂的乙酸乙酯可溶部分中分离出两种新的2,4'-环氧-8,5'-新木脂素（1和2），以及五种已知的7,9';7',9-二环氧木脂素（3-7）。通过广泛的光谱分析和电子圆二色性（ECD）计算阐明了它们的结构和绝对构型。这是关于植物中2,4'-环氧-8,5'-新木脂素的第二篇报道。化合物2、6和7在5 μM浓度下对乙酰氨基酚诱导的肝细胞损伤具有体外保护活性。
