POEMS综合征中C反应蛋白-3和血管内皮生长因子：一项为期2年的纵向研究。

Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study.

作者信息

Briani Chiara, Dalla Torre Chiara, Lessi Federica, Cavallaro Tiziana, Scarlato Marina, Ferrari Sergio, Campagnolo Marta, Lucchetta Marta, Cabrini Ilaria, Morbin Michela, Lauria Giuseppe, Adami Fausto, Manfredi Angelo A

机构信息

Department of Neurosciences, Sciences NPSRR, University of Padova, Italy.

出版信息

J Neuroimmunol. 2014 Dec 15;277(1-2):189-92. doi: 10.1016/j.jneuroim.2014.09.021. Epub 2014 Oct 5.

DOI:10.1016/j.jneuroim.2014.09.021

PMID:25447599

Abstract

Circulating Pentraxin 3 (PTX3) and vascular endothelial growth factor (VEGF) levels were measured longitudinally (mean follow-up 2 years) by ELISA in 6 patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome and 16 controls. Expression of PTX3 was also assessed (immunohistochemistry) on sural nerve biopsies from POEMS and vasculitic neuropathy patients. No correlation was found between PTX3 and VEGF levels in POEMS or controls. Sural nerve biopsies from vasculitic neuropathy patients, but not those from POEMS syndrome, showed strong PTX3 staining. PTX3, expression of vessel inflammation/remodeling, and VEGF, crucial pro-angiogenic cytokine, appear to be independently regulated in POEMS syndrome.

摘要

通过酶联免疫吸附测定法（ELISA）对6例患有多发性神经病、器官肿大、内分泌病、M蛋白、皮肤改变（POEMS）综合征的患者及16名对照者进行了纵向（平均随访2年）循环五聚体蛋白3（PTX3）和血管内皮生长因子（VEGF）水平的测定。还对POEMS综合征患者和血管炎性神经病患者的腓肠神经活检组织进行了PTX3表达评估（免疫组织化学法）。在POEMS综合征患者或对照者中，未发现PTX3与VEGF水平之间存在相关性。血管炎性神经病患者的腓肠神经活检组织显示PTX3染色强，但POEMS综合征患者的活检组织未显示。在POEMS综合征中，血管炎症/重塑的标志物PTX3的表达和关键的促血管生成细胞因子VEGF似乎受到独立调节。