B 群链球菌荚膜多糖在人血浆存在的情况下介导生物膜的形成。
Capsular polysaccharide of Group B Streptococcus mediates biofilm formation in the presence of human plasma.
机构信息
Institut Pasteur, Unité des Bactéries Pathogènes à Gram positif, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS ERL 3526), France.
Institut Pasteur, Imagopole, 75015 Paris, France.
出版信息
Microbes Infect. 2015 Jan;17(1):71-76. doi: 10.1016/j.micinf.2014.10.007. Epub 2014 Oct 27.
Group B Streptococcus (GBS) is an asymptomatic colonizer of human mucosal surfaces that is responsible for sepsis and meningitis in neonates. Bacterial persistence and pathogenesis often involves biofilm formation. We previously showed that biofilm formation in medium supplemented with glucose is mediated by the PI-2a pilus. Here, biofilm formation was tested in cell culture medium supplemented with human plasma. GBS strains were able to form biofilms in these conditions unlike Group A Streptococcus (GAS) or Staphylococcus aureus. Analysis of mutants impaired for various surface components revealed that the GBS capsule is a key component in this process.
B 群链球菌（GBS）是一种无症状的人类黏膜表面定植菌，可导致新生儿败血症和脑膜炎。细菌的持续存在和发病机制常涉及生物膜的形成。我们之前的研究表明，在补充葡萄糖的培养基中，生物膜的形成是由 PI-2a 菌毛介导的。在这里，我们在补充人血浆的细胞培养基中测试了生物膜的形成。与 A 群链球菌（GAS）或金黄色葡萄球菌不同，GBS 菌株能够在这些条件下形成生物膜。对各种表面成分缺失突变体的分析表明，GBS 荚膜是该过程的关键成分。
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