Valero C, Javierre E, García-Aznar J M, Menzel A, Gómez-Benito M J
Structural and SolidsMechanics Division, Mechanical Engineering Department, Multiscale in Mechanical and Biological Engineering (M2BE), Aragón Institute of Engineering Research (I3A), University of Zaragoza, María de Luna 3, 50018, Saragossa, Spain,
Ann Biomed Eng. 2015 Jul;43(7):1654-65. doi: 10.1007/s10439-014-1200-8. Epub 2014 Dec 2.
Numerical models have become one of the most powerful tools in biomechanics and mechanobiology allowing highly detailed simulations. One of the fields in which they have broadly evolved during the last years is in soft tissue modeling. Particularly, wound healing in the skin is one of the processes that has been approached by computational models due to the difficulty of performing experimental investigations. During the last decades wound healing simulations have evolved from numerical models which considered only a few number of variables and simple geometries to more complex approximations that take into account a higher number of factors and reproduce more realistic geometries. Moreover, thanks to improved experimental observations, a larger number of processes, such as cellular stress generation or vascular growth, that take place during wound healing have been identified and modeled. This work presents a review of the most relevant wound healing approximations, together with an identification of the most relevant criteria that can be used to classify them. In addition, and looking towards the actual state of the art in the field, some future directions, challenges and improvements are analyzed for future developments.
数值模型已成为生物力学和力学生物学中最强大的工具之一，可实现高度详细的模拟。在过去几年中，它们广泛发展的领域之一是软组织建模。特别是，由于进行实验研究存在困难，皮肤伤口愈合是计算模型所涉及的过程之一。在过去几十年中，伤口愈合模拟已从仅考虑少数变量和简单几何形状的数值模型发展到考虑更多因素并再现更逼真几何形状的更复杂近似。此外，由于改进的实验观察，已识别并建模了伤口愈合过程中发生的大量过程，如细胞应激产生或血管生长。这项工作对最相关的伤口愈合近似进行了综述，并确定了可用于对其进行分类的最相关标准。此外，展望该领域的实际技术水平，分析了未来发展的一些未来方向、挑战和改进。
