Autoimmun Rev. 2015 Jan;14(1):75-9. doi: 10.1016/j.autrev.2014.10.003.
Recent research in systemic lupus erythematosus (SLE) yielded new antigens and antibodies in SLE patients. We describe the various autoantibodies that can be detected in patients with SLE. A literature review, using the terms “autoantibody” and “systemic lupus erythematosus”, was conducted to search for articles on autoantibodies in SLE, their target antigens, association with disease activity and other clinical manifestations. One hundred and eighty autoantibodies were so far described in SLE patients. These include autoantibodies that target nuclear antigens, cytoplasmic antigens, cell membrane antigens, phospholipid-associated antigens, blood cells, endothelial cells, and nervous system antigens, plasma proteins, matrix proteins, and miscellaneous antigens. The target of an autoantibody, the autoantigen properties, autoantibody frequencies in SLE, as well as clinical associations, and correlation with disease activity are described for all 180 autoantibodies. SLE is so far the autoimmune disease with the largest number of detectable autoantibodies. Their production could be antigen-driven, the result of a polyclonal B cell activation, impaired apoptotic pathways, or the outcome of an idiotypic network dysregulation.
最近的系统性红斑狼疮（SLE）研究在 SLE 患者中发现了新的抗原和抗体。我们描述了可在 SLE 患者中检测到的各种自身抗体。使用“自身抗体”和“系统性红斑狼疮”这两个术语进行了文献复习，以搜索关于 SLE 中自身抗体、其靶抗原、与疾病活动和其他临床表现的关联的文章。到目前为止，在 SLE 患者中已经描述了 180 种自身抗体。这些包括针对核抗原、细胞质抗原、细胞膜抗原、磷脂相关抗原、血细胞、内皮细胞和神经系统抗原、血浆蛋白、基质蛋白和各种抗原的自身抗体。描述了所有 180 种自身抗体的自身抗体的靶标、自身抗原特性、SLE 中的自身抗体频率以及与临床的关联，以及与疾病活动的相关性。SLE 是迄今为止可检测到的自身抗体数量最多的自身免疫性疾病。它们的产生可能是抗原驱动的，多克隆 B 细胞激活的结果，凋亡途径受损，或独特型网络失调的结果。
