Oliveira Sergio C
Universidade Federal de Minas Gerais, Departamento de Bioquímica e Imunologia, Av. Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil.
Microbes Infect. 2014 Dec;16(12):977-8. doi: 10.1016/j.micinf.2014.10.003. Epub 2014 Oct 15.
The innate immune system is important as the first line of defense to sense invading pathogens. Nucleic acids represent critical pathogen signatures that trigger a host proinflammatory immune response. Much progress has been made in understanding how DNA and RNA trigger host defense countermeasures, however, several aspects of how cytosolic nucleic acids are sensed remain unclear. This special issue reviews how the host innate immune system senses nucleic acids from Brucella abortus, Mycobacterium sp and Legionella pneumophila, viral DNA, the role of STING in DNA sensing and inflammatory diseases and the mechanism of viral RNA recognition by the small interfering RNA pathway in Drosophila melanogaster.
先天免疫系统作为感知入侵病原体的第一道防线至关重要。核酸是触发宿主促炎免疫反应的关键病原体标志。在理解DNA和RNA如何触发宿主防御对策方面已经取得了很大进展，然而，胞质核酸的感知方式的几个方面仍不清楚。本期特刊综述了宿主先天免疫系统如何感知来自流产布鲁氏菌、分枝杆菌属和嗜肺军团菌的核酸、病毒DNA、STING在DNA感知和炎症性疾病中的作用以及果蝇中小干扰RNA途径识别病毒RNA的机制。
