Chinta Supriya, Wallang Batriti S, Sachdeva Virender, Gupta Amit, Patil-Chhablani Preeti, Kekunnaya Ramesh
Jasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, KAR Campus, Banjara Hills, Hyderabad, India.
Indian J Ophthalmol. 2014 Oct;62(10):1003-7. doi: 10.4103/0301-4738.145996.
Optic nerve atrophy is an important ophthalmological sign that may be associated with serious systemic conditions having a significant bearing on the overall morbidity of the child. Studies specific to etiology of childhood optic atrophy are scarce, this being the first such study from India to the best of our knowledge.
The aim was to analyze the clinical features and etiology of diagnosed cases of optic nerve atrophy in children <16 years of age.
Retrospective review of records of children diagnosed with optic nerve atrophy between the ages of 0 and 16 years from 2006 to 2011.
A total of 324 children (583 eyes) were identified. Among these 160 (49%) presented with defective vision, 71 (22%) with strabismus, 18 (6%) with only nystagmus. Rest had a combination of two or three of the above symptoms. Sixty-five patients (20%) had a unilateral affection. Hypoxic ischemic encephalopathy seen in 133 patients (41%) was the most frequent cause of childhood optic atrophy, followed by idiopathic in 98 (30%), hydrocephalus in 24 (7%), compressive etiology in 18 (5%), infective in 19 (6%), congenital in 6 (2%), inflammatory in 5 (2%) patients, respectively.
Hypoxic ischemic encephalopathy appears to be the most common cause of optic atrophy in children in this series. The most common presenting complaint was defective vision.
视神经萎缩是一种重要的眼科体征，可能与严重的全身性疾病相关，这些疾病对儿童的整体发病率有重大影响。关于儿童视神经萎缩病因的具体研究很少，据我们所知，这是印度的第一项此类研究。
分析16岁以下儿童视神经萎缩确诊病例的临床特征和病因。
回顾性分析2006年至2011年期间0至16岁被诊断为视神经萎缩的儿童的病历。
共确定324名儿童（583只眼）。其中160名（49%）有视力缺陷，71名（22%）有斜视，18名（6%）仅有眼球震颤。其余患者有上述两种或三种症状的组合。65名患者（20%）为单侧受累。133名患者（41%）出现的缺氧缺血性脑病是儿童视神经萎缩最常见的原因，其次是特发性98例（30%）、脑积水24例（7%）、压迫性病因18例（5%）、感染性19例（6%）、先天性6例（2%）、炎症性5例（2%）。
在本系列研究中，缺氧缺血性脑病似乎是儿童视神经萎缩最常见的原因。最常见的主诉是视力缺陷。
