Lin Shan-Yang
Laboratory of Pharmaceutics and Biopharmaceutics, Department of Biotechnology and Pharmaceutical Technology, Yuanpei University, Hsin Chu, Taiwan, ROC.
Drug Discov Today. 2015 Feb;20(2):209-22. doi: 10.1016/j.drudis.2014.10.001. Epub 2014 Oct 19.
Here, I provide an overview of the solid-state characteristics, phase transformations and chemical reactions of metoclopramide hydrochloride monohydrate (MCP HCl H2O). Three unique techniques, including thermoanalytical methods, one-step simultaneous differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) microspectroscopy, and hot-stage microscopic (HSM) imaging, have been applied to study the solid-state phase transitions of MCP HCl H2O in continuous dehydration, amorphization and recrystallization processes. I also review the effects of grinding or heating on ion-exchange reactions, milling, compression or colyophilization on Maillard reactions, and γ-ray irradiation or electron beams on radiolysis in the solid state. I also report the exposure of MCP HCl H2O in solution to light, irradiation, oxidants or π-acceptors. This review will serve as a useful keynote for the evolving realm of solid-state chemistry research.
在此，我概述了盐酸甲氧氯普胺一水合物（MCP HCl H₂O）的固态特性、相变和化学反应。三种独特的技术，包括热分析方法、一步同时差示扫描量热法（DSC）和傅里叶变换红外（FTIR）显微光谱法，以及热台显微镜（HSM）成像，已被用于研究MCP HCl H₂O在连续脱水、非晶化和重结晶过程中的固态相变。我还回顾了研磨或加热对离子交换反应的影响、研磨、压缩或冷冻干燥对美拉德反应的影响，以及γ射线辐照或电子束对固态辐射分解的影响。我还报告了MCP HCl H₂O在溶液中暴露于光、辐照、氧化剂或π受体的情况。这篇综述将为固态化学研究不断发展的领域提供有用的主旨。
