Knox-Macaulay H H
Department of Medicine, Connaught Hospital, Freetown, Sierra Leone.
Afr J Med Med Sci. 1989 Mar;18(1):75-81.
Using 51Cr, 125I, and 59Fe, red cell survival, blood volumes and certain aspects of iron metabolism were investigated in Sierra Leoneans referred for further evaluation of various blood disorders. The data provided clarification of the nature of the anaemia in some patients and demonstrated the haemolytic and erythropoietic role of the spleen in others with splenomegaly. Blood volume values in healthy individuals were found to be similar to those of normal subjects in other populations. Increased plasma volumes commonly described in non-African patients with anaemia and splenomegaly were also recorded in this group of Sierra Leoneans. Information obtained from these studies indicates that facilities for radioisotope investigations would be an asset in the diagnostic evaluation of complex blood disorders and in haematological research in developing African countries.
利用51铬、125碘和59铁，对因各种血液疾病前来进一步评估的塞拉利昂人进行了红细胞存活、血容量及铁代谢某些方面的研究。这些数据澄清了部分患者贫血的性质，并表明脾脏在其他脾肿大患者中具有溶血和促红细胞生成作用。发现健康个体的血容量值与其他人群中的正常受试者相似。在这组塞拉利昂人中也记录到了非非洲贫血和脾肿大患者中常见的血浆量增加情况。从这些研究中获得的信息表明，放射性同位素检测设备将有助于非洲发展中国家对复杂血液疾病进行诊断评估及开展血液学研究。
