Chu Lan Hoang, Gangopadhyay Anu, Dorfleutner Andrea, Stehlik Christian
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1.
The PYRIN domain (PYD) is a protein-protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling function in innate immune responses and particularly in the assembly of inflammasomes, which are large protein complexes that allow the induced proximity-mediated activation of caspase-1 and subsequently the release of pro-inflammatory cytokines. The molecular mechanism of inflammasome assembly was only recently elucidated and specifically requires PYD oligomerization. Here we discuss the recent advances in our understanding of PYD signaling and its regulation by PYD-only proteins.
PYRIN结构域(PYD)是一种蛋白质-蛋白质相互作用结构域,属于死亡结构域折叠(DDF)超家族。它因其在先天免疫反应中的信号传导功能而闻名,特别是在炎性小体的组装中,炎性小体是一种大型蛋白质复合物,能够使半胱天冬酶-1通过诱导邻近介导的方式激活,随后释放促炎细胞因子。炎性小体组装的分子机制直到最近才被阐明,并且特别需要PYD寡聚化。在这里,我们讨论了我们对PYD信号传导及其仅由PYD结构域组成的蛋白质调控的最新认识进展。