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An updated view on the structure and function of PYRIN domains.
Apoptosis. 2015 Feb;20(2):157-73. doi: 10.1007/s10495-014-1065-1.
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Inhibiting the inflammasome: one domain at a time.
Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290.
3
Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.
J Biol Chem. 2014 Aug 22;289(34):23504-19. doi: 10.1074/jbc.M114.553305. Epub 2014 Jul 8.
5
Self-oligomerization of ASC PYD domain prevents the assembly of inflammasome in vitro.
Appl Biochem Biotechnol. 2014 Apr;172(8):3902-12. doi: 10.1007/s12010-014-0819-0. Epub 2014 Mar 2.
6
ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides.
Mol Immunol. 2015 Oct;67(2 Pt B):294-302. doi: 10.1016/j.molimm.2015.06.013. Epub 2015 Jul 2.
7
Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity.
J Biol Chem. 2010 Aug 27;285(35):27402-27410. doi: 10.1074/jbc.M110.113191. Epub 2010 Jun 11.
8
Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.
Biochemistry. 2005 Jan 18;44(2):575-83. doi: 10.1021/bi048374i.
9
Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly.
J Biol Chem. 2011 Nov 11;286(45):39528-36. doi: 10.1074/jbc.M111.278812. Epub 2011 Aug 31.
10
Purification and analysis of the interactions of caspase-1 and ASC for assembly of the inflammasome.
Appl Biochem Biotechnol. 2015 Mar;175(6):2883-94. doi: 10.1007/s12010-014-1471-4. Epub 2015 Jan 8.

引用本文的文献

1
The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members.
iScience. 2025 Apr 11;28(5):112413. doi: 10.1016/j.isci.2025.112413. eCollection 2025 May 16.
3
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Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits.
EMBO Mol Med. 2024 Apr;16(4):678-699. doi: 10.1038/s44321-024-00046-w. Epub 2024 Mar 11.
5
Nanoscale organization of the endogenous ASC speck.
iScience. 2023 Nov 2;26(12):108382. doi: 10.1016/j.isci.2023.108382. eCollection 2023 Dec 15.
6
Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities.
Front Immunol. 2023 Jul 20;14:1232629. doi: 10.3389/fimmu.2023.1232629. eCollection 2023.
7
POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
Front Immunol. 2022 Sep 26;13:912069. doi: 10.3389/fimmu.2022.912069. eCollection 2022.
8
complex formation of human PYRIN domain-only protein 3 prevented by self-oligomerization of ASC PYD domain.
Saudi J Biol Sci. 2021 Mar;28(3):1607-1614. doi: 10.1016/j.sjbs.2020.12.049. Epub 2021 Jan 5.
9
Tissue-selective alternate promoters guide NLRP6 expression.
Life Sci Alliance. 2020 Dec 29;4(3). doi: 10.26508/lsa.202000897. Print 2021 Mar.
10
An overview of the non-canonical inflammasome.
Mol Aspects Med. 2020 Dec;76:100924. doi: 10.1016/j.mam.2020.100924. Epub 2020 Nov 11.

本文引用的文献

1
IKKα negatively regulates ASC-dependent inflammasome activation.
Nat Commun. 2014 Sep 30;5:4977. doi: 10.1038/ncomms5977.
2
Regulated cell death: signaling and mechanisms.
Annu Rev Cell Dev Biol. 2014;30:337-56. doi: 10.1146/annurev-cellbio-100913-013226. Epub 2014 Aug 13.
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Crystal structure of a complex of NOD1 CARD and ubiquitin.
PLoS One. 2014 Aug 15;9(8):e104017. doi: 10.1371/journal.pone.0104017. eCollection 2014.
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Inflammatory caspases are innate immune receptors for intracellular LPS.
Nature. 2014 Oct 9;514(7521):187-92. doi: 10.1038/nature13683. Epub 2014 Aug 6.
5
cASCading specks.
Nat Immunol. 2014 Aug;15(8):698-700. doi: 10.1038/ni.2942.
6
Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions.
Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):2007-18. doi: 10.1107/S1399004714010311. Epub 2014 Jun 29.
7
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.
8
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22.
9
A critical role for human caspase-4 in endotoxin sensitivity.
J Immunol. 2014 Jul 1;193(1):335-43. doi: 10.4049/jimmunol.1303424. Epub 2014 May 30.
10
The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4.
Genes Immun. 2014 Sep;15(6):392-403. doi: 10.1038/gene.2014.30. Epub 2014 May 29.

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