Basic Research Laboratory, Stem Cell Regulation and Animal Aging Section, National Cancer Institute, Frederick, MD 21702, USA.
Cancer Lett. 2015 Jan 28;356(2 Pt A):301–8. doi: 10.1016/j.canlet.2014.10.011.
The major goal of cancer therapy is to destroy cancer cells without harming normal cells. However, because cancer cells have incredible heterogeneity and adaptability, it is difficult to target them therapeutically. Metabolic reprogramming has emerged as a common feature of cancer. Ever since microRNAs (miRNAs) have been found to influence metabolism, researchers have been trying to address the connection between cancer cells and specific miRNAs. Many of the well-known miRNAs relate to crucial genes that can impact metabolic pathways, both negatively and positively. With a better understanding of how different pathways are affected, the roles of miRNAs will be more transparent, which could lead to the discovery of new ideas about the concept of tumorigenesis and other cancer-related topics.
癌症治疗的主要目标是在不伤害正常细胞的情况下杀死癌细胞。然而,由于癌细胞具有令人难以置信的异质性和适应性,因此很难对其进行治疗。代谢重编程已成为癌症的共同特征。自从发现 microRNAs(miRNAs)可以影响代谢以来,研究人员一直试图解决癌细胞与特定 miRNAs 之间的联系。许多众所周知的 miRNAs 与关键基因有关,这些基因可以对代谢途径产生正反两方面的影响。随着对不同途径受影响方式的深入了解,miRNAs 的作用将更加清晰,这可能会导致发现有关肿瘤发生和其他癌症相关主题的新概念。