Li Hao-Bo, Zhang Ying-Huai, Chen Hui-Zhen, Chen Yong
Oral Medicine Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.
Oral Surgery Department, Central Hospital of Cangzhou, Cangzhou, Hebei 061000, P.R. China.
Exp Ther Med. 2015 Jan;9(1):203-206. doi: 10.3892/etm.2014.2053. Epub 2014 Nov 6.
hMSH2 is one of the human DNA mismatch repair genes that plays an important role in reducing mutations and maintaining genomic stability. The aim of the present study was to detect the expression and significance of hMSH2 protein in patients with oral lichen planus (OLP). The expression levels of hMSH2 in the OLP group (n=51) and control group with normal oral mucosa (NM; n=40) were detected using an immunohistochemical method and subsequently assessed. The positive rate of hMSH2 expression in the OLP group was 52.94%, while the rate was 80% in the control group, exhibiting a statistically significant difference (χ=7.1993; P<0.05). However, the expression of hMSH2 in the OLP tissues was not shown to significantly correlate with the patient gender, age and type of OLP (P>0.05). In conclusion, the protein expression levels of hMSH2 in the OLP tissues were significantly reduced as compared with that in the NM tissues, indicating that hMSH2 plays a role in the development of OLP. Therefore, hMSH2 may be used as a biomarker for evaluating the cancer risk of patients with OLP.
hMSH2是人类DNA错配修复基因之一，在减少突变和维持基因组稳定性方面发挥着重要作用。本研究的目的是检测hMSH2蛋白在口腔扁平苔藓（OLP）患者中的表达及意义。采用免疫组织化学方法检测OLP组（n = 51）和正常口腔黏膜（NM）对照组（n = 40）中hMSH2的表达水平，随后进行评估。OLP组中hMSH2表达的阳性率为52.94%，而对照组为80%，差异具有统计学意义（χ = 7.1993；P < 0.05）。然而，hMSH2在OLP组织中的表达与患者性别、年龄及OLP类型均无显著相关性（P > 0.05）。总之，与NM组织相比，OLP组织中hMSH2的蛋白表达水平显著降低，表明hMSH2在OLP的发生发展中起作用。因此，hMSH2可作为评估OLP患者癌症风险的生物标志物。
