Odette Cancer Centre, Sunnybrook Health Sciences Centre , Toronto, ON , Canada ; Department of Radiation Oncology, University of Toronto , Toronto, ON , Canada.
Odette Cancer Centre, Sunnybrook Health Sciences Centre , Toronto, ON , Canada ; Department of Radiation Oncology, University of Toronto , Toronto, ON , Canada ; Department of Health Policy, Measurement and Evaluation, University of Toronto , Toronto, ON , Canada.
Front Oncol. 2014 Nov 14;4:313. doi: 10.3389/fonc.2014.00313. eCollection 2014.
Stereotactic ablative body radiotherapy (SABR) is a newer method of ultra hypo fractionated radiotherapy that uses combination of image-guided radiotherapy (IGRT) and intensity-modulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT), to deliver high doses of radiation in a few fractions to a target, at the same time sparing the surrounding organs at risk (OAR). SABR is ideal for treating small volumes of disease and has been introduced in a number of disease sites including brain, lung, liver, spine, and prostate. Given the radiobiological advantages of treating prostate cancer with high doses per fraction, SABR is becoming a standard of care for low and intermediate-risk prostate cancer patients based upon the results from Sunnybrook and also the US-based prostate SABR consortium. This review examines the development of moderate and ultra hypo-fractionation schedules at the Odette Cancer centre, Sunnybrook Health Sciences. Moderate hypo-fractionation protocol was first developed in 2001 for intermediate-risk prostate cancer and from there on different treatment schedules including SABR evolved for all risk groups.
立体定向消融体放射治疗（SABR）是一种超分割放射治疗的新方法，它结合了图像引导放射治疗（IGRT）和强度调制放射治疗（IMRT）或容积旋转调强放射治疗（VMAT），以在几次分割中将高剂量的辐射传递到目标，同时保护周围的危险器官（OAR）。SABR 非常适合治疗小体积的疾病，已经在许多疾病部位得到应用，包括脑、肺、肝、脊柱和前列腺。由于高剂量分割治疗前列腺癌具有放射生物学优势，基于 Sunnybrook 的研究结果以及美国前列腺 SABR 联合研究，SABR 已成为低危和中危前列腺癌患者的标准治疗方法。本文回顾了在 Odette 癌症中心，Sunnybrook 健康科学中心开展的中分割和超分割治疗方案的进展。中分割方案于 2001 年首次为中危前列腺癌开发，此后为所有风险组开发了不同的治疗方案，包括 SABR。
