Kulkarni Sameer D, Sinha Barij N, Kumar K Jayaram
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India.
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India.
Int J Biol Macromol. 2015 Jan;72:1005-12. doi: 10.1016/j.ijbiomac.2014.10.007. Epub 2014 Oct 17.
Modified starches play a crucial role in the pharmaceutical industries in controlling the drug release at a pre-determined rate. The effect of acetylation on the physicochemical and drug release characteristics of the starches from five different Indian L. siceraria cultivars was investigated. Starches isolated from the seeds of L. siceraria were subjected to varying degrees of acetylation. Using a range of characterization methods including amylose content, elemental analysis, light transmittance, swelling power, scanning electron microscopy, FT-IR and X-ray diffraction, the effect of acetylation was determined. The swelling power of starch acetates improved significantly (P < 0.05) with the increase in degree of substitution. The increase in swelling shows that acetylation improved the accessibility of an amorphous area to the water. The formation of V-type of complex crystalline structures confirmed the acetylation of L. siceraria starch. Modification in the crystalline structure of starch acetate retarded the drug release, which is controlled by water uptake. The starch acetates from all the cultivars showed better sustained release properties with the increase in degree of substitution. Drug release through the swellable matrix was found to be controlled by fickian diffusion from the gel layer as indicated by Korsmeyer-Peppas models (R(2)) 0.9885-0.9984.
变性淀粉在制药行业中起着至关重要的作用，能够以预定速率控制药物释放。研究了乙酰化对来自五个不同印度角豆品种淀粉的物理化学和药物释放特性的影响。从角豆种子中分离出的淀粉进行了不同程度的乙酰化处理。使用一系列表征方法，包括直链淀粉含量、元素分析、透光率、溶胀能力、扫描电子显微镜、傅里叶变换红外光谱和X射线衍射，确定了乙酰化的影响。随着取代度的增加，醋酸淀粉的溶胀能力显著提高（P < 0.05）。溶胀的增加表明乙酰化改善了无定形区域对水的可及性。V型复合晶体结构的形成证实了角豆淀粉的乙酰化。醋酸淀粉晶体结构的改变延缓了药物释放，药物释放受水分吸收控制。所有品种的醋酸淀粉随着取代度的增加均表现出更好的缓释性能。如Korsmeyer-Peppas模型（R(2)）0.9885 - 0.9984所示，通过可溶胀基质的药物释放受凝胶层的菲克扩散控制。
