急性呼吸窘迫综合征中的肥胖与营养
Obesity and nutrition in acute respiratory distress syndrome.
作者信息
Stapleton Renee D, Suratt Benjamin T
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, 149 Beaumont Avenue, Burlington, VT 05405, USA.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont, 149 Beaumont Avenue, Burlington, VT 05405, USA.
出版信息
Clin Chest Med. 2014 Dec;35(4):655-71. doi: 10.1016/j.ccm.2014.08.005. Epub 2014 Sep 24.
Abstract
This article discusses obesity, its contribution to clinical outcomes, and the current literature on nutrition. More than one third of Americans are obese. Literature suggests that, among critically ill patients, the relationship between obesity and outcomes is complex. Obese patients may be at greater risk of developing acute respiratory distress syndrome (ARDS) than normal weight patients. Although obesity may confer greater morbidity in intensive care, it seems to decrease mortality. ARDS is a catabolic state; patients demonstrate a profound inflammatory response, multiple organ dysfunction, and hypermetabolism, often with malnutrition. The concept of pharmaconutrition has emerged.
摘要
本文讨论了肥胖症、其对临床结局的影响以及当前关于营养的文献。超过三分之一的美国人患有肥胖症。文献表明，在重症患者中，肥胖与结局之间的关系很复杂。肥胖患者比正常体重患者发生急性呼吸窘迫综合征（ARDS）的风险可能更高。尽管肥胖症在重症监护中可能会带来更高的发病率，但它似乎会降低死亡率。ARDS是一种分解代谢状态；患者表现出强烈的炎症反应、多器官功能障碍和高代谢，常伴有营养不良。药物营养的概念已经出现。
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