首例免疫球蛋白治疗的肝移植受者中严重副流感病毒 4B 和鼻病毒 C 合并感染报告

First report of severe parainfluenza virus 4B and rhinovirus C coinfection in a liver transplant recipient treated with immunoglobulin.

机构信息

Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region.

Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region; Research Centre of Infection and Immunology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region.

出版信息

J Clin Virol. 2014 Dec;61(4):611-4. doi: 10.1016/j.jcv.2014.09.019. Epub 2014 Oct 8.

DOI:10.1016/j.jcv.2014.09.019

PMID:25453574

Abstract

We describe the first reported case of severe pneumonia due to coinfection by parainfluenza virus type 4B and rhinovirus C in a liver transplant recipient. The patient responded promptly to intravenous immunoglobulin and timely infection control measures prevented spreading of the infections. This report highlights respiratory viral coinfections as a possible cause of severe morbidity in transplant recipients and the importance of efficient molecular diagnostic technologies with major impact on clinical practice in a transplant center. It also describes a potential therapeutic strategy for such patients.

摘要

我们描述了首例因副流感病毒 4B 型和鼻病毒 C 型合并感染导致的肝移植受者严重肺炎病例。该患者对静脉注射免疫球蛋白治疗反应迅速，及时的感染控制措施防止了感染的传播。本报告强调了呼吸道病毒合并感染可能是导致移植受者严重发病的原因之一，并且说明了高效的分子诊断技术对于移植中心临床实践具有重大影响。本报告还描述了此类患者的一种潜在治疗策略。