哮喘、过敏与前列腺癌风险：蒙特利尔PROtEuS研究结果
Asthma, allergy and the risk of prostate cancer: results from the Montreal PROtEuS study.
作者信息
Weiss Deborah, El-Zein Mariam, Rousseau Marie-Claude, Richard Hugues, Karakiewicz Pierre I, Parent Marie-Élise
机构信息
Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada.
Epidemiology and Biostatistics Unit, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada; Department of Social and Preventive Medicine, Université de Montréal, Montréal, Québec, Canada; University of Montreal Hospital Research Centre (CRCHUM), Montréal, Québec, Canada.
出版信息
Cancer Epidemiol. 2014 Dec;38(6):695-9. doi: 10.1016/j.canep.2014.10.003. Epub 2014 Nov 4.
BACKGROUND
The few previous studies examining the association between asthma or allergy and prostate cancer (PCa) risk were inconclusive. This study aimed to evaluate these associations, and to explore in details the possible influence of current versus former allergic condition, age at onset, time since onset, and duration of each allergic condition.
METHODS
Detailed information on self-reported asthma and allergy was collected in the context of a large population-based case-control study conducted in Montreal, Canada. Study subjects included 1936 cases, diagnosed between 2005 and 2009, and 1995 population controls. Unconditional multivariate logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusting for age, ancestry and familial history of prostate cancer.
RESULTS
The ORs were 1.11 (95% CI: 0.89-1.40) and 0.98 (95% CI: 0.84-1.14) for ever reporting of asthma and allergy, respectively. These ORs did not substantially vary according to status (former or current), age at onset, time since onset, and duration of each allergic condition. PCa screening was not associated with allergic diseases reporting.
CONCLUSIONS
Overall, our findings are in line with the absence of an association between a history of asthma or allergy, and PCa risk.
背景
之前关于哮喘或过敏与前列腺癌（PCa）风险之间关联的少数研究尚无定论。本研究旨在评估这些关联，并详细探讨当前与既往过敏状况、发病年龄、发病时间以及每种过敏状况的持续时间可能产生的影响。
方法
在加拿大蒙特利尔进行的一项基于人群的大型病例对照研究中，收集了关于自我报告的哮喘和过敏的详细信息。研究对象包括1936例在2005年至2009年间确诊的病例以及1995名人群对照。采用无条件多因素逻辑回归来估计比值比（OR）和95%置信区间（CI），并对年龄、血统和前列腺癌家族史进行校正。
结果
曾报告哮喘和过敏的OR分别为1.11（95%CI：0.89 - 1.40）和0.98（95%CI：0.84 - 1.14）。这些OR并未根据状况（既往或当前）、发病年龄、发病时间以及每种过敏状况的持续时间而有显著差异。前列腺癌筛查与过敏疾病报告无关。
结论
总体而言，我们的研究结果与哮喘或过敏病史和前列腺癌风险之间不存在关联相符。
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