Premprabha Dhanakom, Sobel Julia, Pua Chris, Chong Karen, Reilly Linda M, Chuter Timothy A M, Hiramoto Jade S
1 Department of Surgery, Prince of Songkla University, Hat Yai, Songkla, Thailand.
J Endovasc Ther. 2014 Dec;21(6):783-90. doi: 10.1583/14-4807R.1.
To identify risk factors for late-occurring branch occlusion following multibranched endovascular repair of thoracoabdominal and pararenal aortic aneurysm.
Out of 120 patients who underwent multibranched endovascular aneurysm repair between September 2005 and May 2013, 100 (78 men; mean age 72.4 ± 7.4 years) met the criteria for inclusion in the current retrospective analysis. Demographic data were gleaned from a prospectively maintained database. Mean aneurysm diameter was 66.7 ± 11.7 mm. Multiplanar reconstructions of postoperative computed tomographic angiography were used to measure 6 parameters of renal branch morphology.
All 100 patients had undergone successful placement of multibranched aortic stent-grafts with a total of 95 celiac branches, 100 superior mesenteric artery (SMA) branches, and 187 renal branches. During a mean follow-up of 25.6 months, there were no stent fractures or stent separations, no SMA occlusions, and only 2 (2.1%) celiac artery occlusions, neither of which required reintervention. In contrast, there were 18 (9.6%) renal branch occlusions in 16 patients, all men (p=0.02). Patients with renal branch occlusions were significantly more likely to have a history of myocardial infarction (p=0.004). The mean renal artery length was significantly greater in the occlusion group compared to the non-occlusion group (47.5 ± 13.6 vs. 39.4 ± 14.2, p=0.03). No other aspect of branch morphology was significantly different between the occlusion and non-occlusion groups.
Renal branch occlusion was by far the commonest late failure mode after multibranched endovascular aneurysm repair. The current study provides no basis for a change in patient selection or stent-graft design, only a change in the components used to construct renal branches. It is too early to tell the effect this will have.
确定胸腹主动脉瘤和肾周主动脉瘤多分支血管腔内修复术后迟发性分支闭塞的危险因素。
在2005年9月至2013年5月期间接受多分支血管腔内动脉瘤修复术的120例患者中,100例(78例男性;平均年龄72.4±7.4岁)符合纳入本次回顾性分析的标准。人口统计学数据来自前瞻性维护的数据库。动脉瘤平均直径为66.7±11.7mm。术后计算机断层血管造影的多平面重建用于测量肾分支形态的6个参数。
所有100例患者均成功植入多分支主动脉覆膜支架,共有95个腹腔干分支、100个肠系膜上动脉(SMA)分支和187个肾分支。在平均25.6个月的随访期间,未发生支架骨折或支架分离,未发生SMA闭塞,仅2例(2.1%)腹腔干闭塞,均无需再次干预。相比之下,16例患者(均为男性)出现18例(9.6%)肾分支闭塞(p=0.02)。有肾分支闭塞的患者心肌梗死病史的可能性显著更高(p=0.004)。与非闭塞组相比,闭塞组的平均肾动脉长度显著更长(47.5±13.6 vs. 39.4±14.2,p=0.03)。闭塞组和非闭塞组在分支形态的其他方面无显著差异。
肾分支闭塞是多分支血管腔内动脉瘤修复术后最常见的迟发性失败模式。本研究没有为患者选择或覆膜支架设计的改变提供依据,只是为构建肾分支所用的组件带来了变化。目前尚无法判断这将产生何种影响。