硝苯地平可阻断人体促肾上腺皮质激素（ACTH）和皮质醇的释放。

Nifedipine blocks ACTH and cortisol release in man.

Jackson R V, Jackson A J, Grice J E, Vella R D

University Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia.

Clin Exp Pharmacol Physiol. 1989 Apr;16(4):257-61. doi: 10.1111/j.1440-1681.1989.tb01554.x.

Abstract

The present study investigated the effect of prior administration of nifedipine on AVP-induced ACTH release in seven normal volunteers. Three protocols were used: 20 mg oral nifedipine; 0.14 pressor units intramuscular (i.m.) per kg bodyweight aqueous AVP; oral nifedipine plus i.m. AVP 90 min later. Plasma ACTH and cortisol were measured at intervals for 2.5 h during each test. 2. The mean peak plasma ACTH and cortisol levels and the mean peak changes from basal in these levels were significantly lower in the nifedipine/AVP test than in the AVP alone test. The integrated area under the cortisol time curve was significantly lower for the nifedipine/AVP test than that for the AVP test alone. Nifedipine alone caused no changes in ACTH or cortisol. 3. Acute administration of oral nifedipine caused an inhibition of AVP-stimulated ACTH and cortisol release in normal humans. This effect may be due to blockade of plasma membrane calcium channels normally activated during AVP stimulation of pituitary corticotrophs.

摘要

本研究调查了硝苯地平预先给药对7名正常志愿者中血管加压素（AVP）诱导促肾上腺皮质激素（ACTH）释放的影响。采用了三种方案：口服20毫克硝苯地平；每千克体重肌肉注射（i.m.）0.14个升压单位的AVP水溶液；口服硝苯地平90分钟后再肌肉注射AVP。在每次测试期间，每隔一段时间测量血浆ACTH和皮质醇水平，持续2.5小时。2. 硝苯地平/AVP测试中血浆ACTH和皮质醇的平均峰值水平以及这些水平相对于基础值的平均峰值变化显著低于单独AVP测试。硝苯地平/AVP测试中皮质醇时间曲线下的积分面积显著低于单独AVP测试。单独使用硝苯地平不会引起ACTH或皮质醇的变化。3. 急性口服硝苯地平会抑制正常人中AVP刺激的ACTH和皮质醇释放。这种效应可能是由于阻断了在AVP刺激垂体促肾上腺皮质细胞过程中通常被激活的质膜钙通道。