Ewen C L, Cino-Ozuna A G, He H, Kerrigan M A, Dekkers J C M, Tuggle C K, Rowland R R R, Wyatt C R
Department of Diagnostic Medicine/Pathobiology, 1800 Denison Avenue, Manhattan, KS 66506, United States.
Department of Animal Science, Iowa State University, Ames, IA 50011, United States.
Vet Immunol Immunopathol. 2014 Dec 15;162(3-4):174-9. doi: 10.1016/j.vetimm.2014.10.003. Epub 2014 Oct 14.
Severe combined immunodeficiency (SCID) is the result of a set of inherited genetic defects which render components of the immune response nonfunctional. In Arabian horses, Jack Russell terriers, and mice, the disorder is a consequence of the absence of T and B lymphocytes, while natural killer (NK) cell and other leukocyte populations remain intact. Preliminary analysis of a naturally acquired form of inherited SCID in a line of pigs showed several defects in the architecture and composition of secondary lymphoid organs. In this study, a quantitative assessment of lymphocyte populations in affected and normal littermates showed depleted T or B lymphocyte populations in affected pigs; however, NK cells and neutrophils were present in numbers comparable to unaffected littermates. The results indicate that the immune defect in pigs shares the same features as other SCID-affected species.
严重联合免疫缺陷（SCID）是一组遗传性基因缺陷的结果，这些缺陷使免疫反应的组成部分失去功能。在阿拉伯马、杰克罗素梗犬和小鼠中，这种疾病是由于缺乏T和B淋巴细胞所致，而自然杀伤（NK）细胞和其他白细胞群体保持完整。对一组猪中自然获得的遗传性SCID形式的初步分析表明，次级淋巴器官的结构和组成存在几个缺陷。在这项研究中，对受影响和正常同窝仔猪的淋巴细胞群体进行定量评估，结果显示受影响的猪中T或B淋巴细胞群体减少；然而，NK细胞和中性粒细胞的数量与未受影响的同窝仔猪相当。结果表明，猪的免疫缺陷与其他受SCID影响的物种具有相同的特征。
