Kaczmarek Monika M, Krawczynski Kamil, Najmula Joanna, Reliszko Zaneta P, Sikora Malgorzata, Gajewski Zdzislaw
Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland; Department for Large Animal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland.
Laboratory of Molecular Biology, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
Reprod Biol. 2014 Dec;14(4):293-7. doi: 10.1016/j.repbio.2014.06.003. Epub 2014 Jul 9.
The objective of this study was to determine the expression profiles of leukemia inhibitory factor (LIF) and its receptor (LIFR), interleukin 6 receptor (IL6R), tumor protein p53 (TP53) and B-cell CLL/lymphoma 2 (BCL2) in the porcine endometrium on selected days of the estrous cycle and pregnancy. Time- and reproductive status (estrous cycle/pregnancy)-specific patterns of expression were identified for all investigated genes. The most pronounced changes were seen on Days 12 and 14 of pregnancy when maternal recognition of pregnancy and implantation, respectively, occurs in pigs.
本研究的目的是确定白血病抑制因子（LIF）及其受体（LIFR）、白细胞介素6受体（IL6R）、肿瘤蛋白p53（TP53）和B细胞淋巴瘤/白血病-2（BCL2）在猪发情周期和妊娠期选定日子的子宫内膜中的表达谱。确定了所有研究基因的时间和生殖状态（发情周期/妊娠）特异性表达模式。在妊娠第12天和第14天观察到最明显的变化，此时猪分别发生母体对妊娠的识别和着床。
