Berger Thomas, Jacobi Christian, Haas Judith, Ransmayr Gerhard, Guger Michael, Zettl Uwe K, Di Pauli Franziska, Taumberger Birgit, Wietek Stefan, Meuer Stefan, Reindl Markus, Giese Thomas
Medical University Innsbruck, Clinical Dept. of Neurology, Anichstrasse 35, 6020 Innsbruck, Austria.
Krankenhaus Nordwest GmbH, Dept. Neurology, Steinbacher Hohl 2-26, 60488 Frankfurt, Germany.
J Neuroimmunol. 2014 Dec 15;277(1-2):145-52. doi: 10.1016/j.jneuroim.2014.10.001. Epub 2014 Oct 12.
Only a fraction of patients do benefit from disease modifying treatments in RRMS and data on IVIG are controversial, it has been suggested that there is a subpopulation of patients with good clinical response to IVIG.
In the prospective, multicenter, open label, exploratory study RRMS patients receiving IVIG therapy were genotyped and several immune parameters were collected.
To distinguish between potential responders and non-responders each of the observed genotypes was combined with the corresponding scores of 65 immune parameters in a stepwise approach. Non-responders were defined as being positive for 4 or more out of 9 individual scores. Responders scored either 0 or 1, while non-responders scored between 7 and 9 (p=1.2∗10(-7)).
In summary, combination of genomic and functional immune parameters allowed prospective discrimination between responders and non-responders towards IVIG therapy in this learning panel of RRMS patients and will be confirmed in a validation study.
