Buzaleh A M, Vazquez E S, Batlle A M
Centro de Investigaciones sobre Porfirinas y Porfirias, CONICET, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina.
Gen Pharmacol. 1989;20(3):323-7. doi: 10.1016/0306-3623(89)90267-x.
The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues.
研究了对小鼠口服慢性给予氰化物的影响。通过这种毒物水平的升高以及肝脏、大脑、心脏和血液中细胞色素氧化酶活性的相应抑制来确认氰化物中毒。测定了解毒酶硫氰酸酶。通过测定氰化物不稳定硫水平来研究硫烷硫池的状态。由于氰化物的作用，硫氰酸酶活性与硫含量之间获得了明显的相关性。这些结果支持了这样一种观点，即硫氰酸酶在氰化物的解毒过程中起着重要作用，可防止氰化物到达靶组织。
