神经肽Y对兔肠系膜动脉细胞外钙离子依赖性收缩的选择性增强作用。

Selective potentiation of extracellular Ca2+-dependent contraction by neuropeptide Y in rabbit mesenteric arteries.

Oshita M, Kigoshi S, Muramatsu I

Department of Pharmacology, Fukui Medical School, Japan.

Gen Pharmacol. 1989;20(3):363-7. doi: 10.1016/0306-3623(89)90274-7.

Abstract

Neuropeptide Y (NPY) potentiated the contractile responses induced by electrical transmural stimulation, noradrenaline and KCl in the rabbit mesenteric artery. 2. In preparations treated with noradrenaline or KCl in Ca2+ free medium, NPY also potentiated the contractile response induced by resupplementation of Ca2+. 3. 3H-efflux from the arteries preincubated with [3H]-noradrenaline was not affected by NPY. 4. These results suggest that NPY selectively acts on the postsynaptic membrane and potentiates the contractions mediated through receptor-operated and voltage-dependent Ca channels.

摘要

神经肽Y（NPY）增强了电跨壁刺激、去甲肾上腺素和氯化钾在兔肠系膜动脉中诱导的收缩反应。2. 在无钙培养基中用去甲肾上腺素或氯化钾处理的标本中，NPY也增强了重新补充钙后诱导的收缩反应。3. 用[3H] - 去甲肾上腺素预孵育的动脉的3H外流不受NPY影响。4. 这些结果表明，NPY选择性作用于突触后膜，并增强通过受体操纵性和电压依赖性钙通道介导的收缩。