Invernizzi R, Paulli M, Rosso R, De Fazio P, Perugini O, Kindl S, Boveri E, Volpato L, Magrini U, Ascari E
Haematologica. 1989 Mar-Apr;74(2):155-9.
A case of large cell lymphoma presenting with hemophagocytic syndrome is reported. The clinicopathological findings suggested a diagnosis of malignant histiocytosis, but on the basis of immunohistological studies Ki-l lymphoma was diagnosed. Neoplastic cells expressed activation antigens such as HLA-DR, IL 2R, T10 and Ki-l, and showed high proliferative activity, but were devoid of T and B cell markers. The high percentage of reactive macrophages found in the bone marrow and lymph node probably reflected the release of lymphokines by the tumor population. The patient was treated with aggressive chemotherapy and is in complete remission at 8 months from diagnosis.
报告了一例表现为噬血细胞综合征的大细胞淋巴瘤。临床病理结果提示为恶性组织细胞增多症，但基于免疫组织学研究诊断为Ki-1淋巴瘤。肿瘤细胞表达激活抗原如HLA-DR、IL-2R、T10和Ki-1，并显示出高增殖活性，但缺乏T和B细胞标志物。在骨髓和淋巴结中发现的高比例反应性巨噬细胞可能反映了肿瘤细胞群释放的淋巴因子。该患者接受了积极的化疗，自诊断后8个月处于完全缓解状态。
