Yazir Yusufhan, Utkan Tijen, Gacar Nejat, Aricioglu Feyza
Kocaeli University Faculty of Medicine, Department of Histology and Embryology, Kocaeli, Turkey.
Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey; Kocaeli University Experimental Medical Research and Application Centre, Kocaeli, Turkey.
Physiol Behav. 2015 Jan;138:297-304. doi: 10.1016/j.physbeh.2014.10.010. Epub 2014 Oct 22.
A number of studies have recently focused on the neuroprotective and anti-inflammatory effects of resveratrol. In prior studies, we described its beneficial effects on scopolamine-induced learning deficits in rats. The aim of this study was to investigate the effects of resveratrol on emotional and spatial cognitive functions, neurotropic factor expression, and plasma levels of proinflammatory cytokines in rats exposed to chronic unpredictable mild stress (CUMS), which is known to induce cognitive deficits. Resveratrol (5 or 20mg/kg) was administered intraperitoneally for 35 days. Rats in the CUMS group and in the 5mg/kg resveratrol+CUMS group performed poorly in tasks designed to assess emotional and spatial learning and memory. The 20mg/kg resveratrol+CUMS group showed improved performance compared to the CUMS group. In addition, the CUMS procedure induced lower expression of brain-derived neurotrophic factor and c-Fos in hippocampal CA1 and CA3 and in the amygdala of stressed rats. These effects were reversed by chronic administration of resveratrol (20mg/kg). In addition, plasma levels of tumor necrosis factor-alpha and interleukin-1 beta were increased by CUMS, but were restored to normal by resveratrol. These results indicate that resveratrol significantly attenuates the deficits in emotional learning and spatial memory seen in chronically stressed rats. These effects may be related to resveratrol-mediated changes in neurotrophin factor expression in hippocampus and in levels of proinflammatory cytokines in circulation.
最近，多项研究聚焦于白藜芦醇的神经保护和抗炎作用。在之前的研究中，我们描述了其对东莨菪碱诱导的大鼠学习缺陷的有益影响。本研究的目的是调查白藜芦醇对暴露于慢性不可预测轻度应激（CUMS）的大鼠的情绪和空间认知功能、神经营养因子表达以及促炎细胞因子血浆水平的影响，已知CUMS会诱发认知缺陷。白藜芦醇（5或20mg/kg）腹腔注射给药35天。CUMS组和5mg/kg白藜芦醇+CUMS组的大鼠在旨在评估情绪和空间学习及记忆的任务中表现不佳。与CUMS组相比，20mg/kg白藜芦醇+CUMS组的表现有所改善。此外，CUMS程序导致应激大鼠海马CA1和CA3以及杏仁核中脑源性神经营养因子和c-Fos的表达降低。长期给予白藜芦醇（20mg/kg）可逆转这些影响。此外，CUMS使肿瘤坏死因子-α和白细胞介素-1β的血浆水平升高，但白藜芦醇可使其恢复正常。这些结果表明，白藜芦醇可显著减轻长期应激大鼠出现的情绪学习和空间记忆缺陷。这些作用可能与白藜芦醇介导的海马神经营养因子表达变化以及循环中促炎细胞因子水平有关。
