Bonser R S, Fragomeni L S, Jamieson S W
Minnesota Heart and Lung Institute, University of Minnesota, Minneapolis 55455.
Invest Radiol. 1989 Apr;24(4):310-22. doi: 10.1097/00004424-198904000-00010.
Since the successful clinical reintroduction of heart and lung transplantation in 1981, more than 350 of these procedures have been performed worldwide. Although survival following this operation is less than that reported for heart transplantation, the results are improving. It is clear that the increased technical difficulty of the procedure combined with the exquisite susceptibility of the transplanted lung to postoperative injury from infection, rejection or other causes account for these differences. In this report we provide an overview of the experience in heart-lung transplantation and discuss recent advances. The late complication of chronic obliterative bronchiolitis, which may progress inexorably, has cast a shadow over the potential long-term success of this therapeutic procedure. Current research efforts are directed toward the cause, diagnosis, and treatment of this complication.
自1981年心肺移植成功重新应用于临床以来，全球已进行了350多例此类手术。尽管该手术后的生存率低于心脏移植报告的生存率，但结果正在改善。显然，该手术技术难度增加，再加上移植肺对感染、排斥或其他原因引起的术后损伤极为敏感，导致了这些差异。在本报告中，我们概述了心肺移植的经验并讨论了近期进展。慢性闭塞性细支气管炎这一晚期并发症可能会无情地进展，给这种治疗方法潜在的长期成功蒙上了一层阴影。目前的研究工作针对该并发症的病因、诊断和治疗。
