Dolgushin Mikhail B, Pronin Igor N, Holodny Elena A, Fadeeva Liudmila M, Holodny Andrei I, Kornienko Valeri N
Department of Neuroradiology, Burdenko Institute of Neurosurgery, Moscow, Russia.
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Clin Imaging. 2015 Jan-Feb;39(1):9-14. doi: 10.1016/j.clinimag.2014.10.006. Epub 2014 Oct 16.
Thirty-six metastases in 22 patients were studied prospectively using computed tomography perfusion. Regions of interests were drawn around: the enhancing part of the tumor, necrotic central part, periphery, peritumoral edema, and normal white matter. Cerebral blood volume, cerebral blood flow, and mean transit time were calculated for each zone. The enhancing part of the tumor significantly differed from the other zones in 11 of 12. Metastases of different primaries can be differentiated from one another with statistically significance (P<.05) by at least one perfusion parameter in 57% of cases.
对22例患者的36处转移灶进行了前瞻性计算机断层灌注研究。在肿瘤强化部分、坏死中央部分、周边、瘤周水肿及正常白质周围绘制感兴趣区。计算每个区域的脑血容量、脑血流量和平均通过时间。肿瘤强化部分在12个中有11个与其他区域有显著差异。在57%的病例中，不同原发灶的转移灶可通过至少一个灌注参数彼此进行有统计学意义（P<0.05）的区分。
