Gulati Seema, Misra Anoop, Nanda Kriti, Pandey Ravindra M, Garg Vivek, Ganguly Sanjeev, Cheung Lorena
Diabetes Foundation (India), SDA, New Delhi, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India.
Diabetes Foundation (India), SDA, New Delhi, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India; Fortis C-DOC Center for Excellence for Diabetes, Metabolic Disease and Endocrinology, New Delhi, India; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India.
Diabetes Metab Syndr. 2015 Oct-Dec;9(4):252-7. doi: 10.1016/j.dsx.2014.10.001. Epub 2014 Nov 1.
This study evaluated the effect of a diabetes specific formula on acute glucose, insulin, and triglyceride responses in patients with type 2 diabetes mellitus (T2DM).
This open-label, randomized, crossover, pilot single center study had two phases (pre-treatment and treatment). After screening, the patients entered run-in period and were counseled on diet and exercise regime. They were then randomly allocated to receive either diabetes specific formula (Nutren Diabetes, Nestlé Health Science, Switzerland; Group A) or isocaloric meal (Cornflakes and milk; Group B). Blood samples were collected to estimate blood glucose, insulin and triglyceride levels (Baseline at 0 min and post-meal at 30, 60, 120, and 180 min).
Area under curve for blood glucose post-meal at 30 min, 60 min, 120 min, and 180 min was significantly lower for Group A as compared with Group B (p=0.003, 0.0001, 0.0001, 0.0001, respectively). Increase in serum insulin levels from baseline was also lower for Group A post-meal at 120 and 180 min, respectively, as compared to Group B (p=0.0001 and 0.0002, respectively).
The Diabetes specific formula tested in this study showed lower post-meal blood glucose and insulin levels as compared with isocaloric meal. Thus, diabetes specific formula may be an option for diabetic and hyperglycemic patients in need of nutritional support.
本研究评估了一种糖尿病专用配方对2型糖尿病（T2DM）患者急性血糖、胰岛素和甘油三酯反应的影响。
这项开放标签、随机、交叉、单中心试点研究有两个阶段（预处理和治疗）。筛选后，患者进入导入期，并接受饮食和运动方案的咨询。然后将他们随机分配接受糖尿病专用配方（纽迪希亚糖尿病全安素，雀巢健康科学公司，瑞士；A组）或等热量餐（玉米片和牛奶；B组）。采集血样以估计血糖、胰岛素和甘油三酯水平（0分钟时的基线水平以及餐后30、60、120和180分钟时的水平）。
与B组相比，A组在餐后30分钟、60分钟、120分钟和180分钟时的血糖曲线下面积显著更低（分别为p = 0.003、0.0001、0.0001、0.0001）。与B组相比，A组在餐后120分钟和180分钟时血清胰岛素水平从基线的升高也更低（分别为p = 0.0001和0.0002）。
本研究中测试的糖尿病专用配方与等热量餐相比，餐后血糖和胰岛素水平更低。因此，糖尿病专用配方可能是需要营养支持的糖尿病和高血糖患者的一种选择。
