Vahedi Fatemeh, Fraleigh Nya, Vlasschaert Caitlyn, McElhaney Janet, Hanifi-Moghaddam Pejman
Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Ontario, Canada; Razi Vaccine & Serum Research Institute, Mashhad, Iran.
Health Sciences North, Sudbury, Ontario K2J 5H4, Canada.
Med Hypotheses. 2014 Dec;83(6):688-93. doi: 10.1016/j.mehy.2014.09.019. Epub 2014 Oct 13.
Granzymes (GZMs) are a class of serine protease, found in cytoplasmic granules of cytotoxic T cells and natural killer cells. The main function of these proteins has been recognized as wiping out viral infections via inducing the apoptosis. This review will highlight inter and intra species differences of GZMs in terms of their functional and structure. These futures may help to device a strategy for isolation of human specific GZMs, which are needed for understating of their role in immune system and devising an effective immune therapy.
颗粒酶（GZMs）是一类丝氨酸蛋白酶，存在于细胞毒性T细胞和自然杀伤细胞的细胞质颗粒中。这些蛋白质的主要功能被认为是通过诱导细胞凋亡来消除病毒感染。本综述将重点介绍颗粒酶在功能和结构方面的种间和种内差异。这些特性可能有助于设计一种分离人类特异性颗粒酶的策略，这对于了解它们在免疫系统中的作用以及设计有效的免疫疗法是必要的。
