Marks David I, Alonso Laura, Radia Rohini
Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Upper Mandlin Street, Bristol BS2 8BJ, UK.
Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Upper Mandlin Street, Bristol BS2 8BJ, UK.
Hematol Oncol Clin North Am. 2014 Dec;28(6):995-1009. doi: 10.1016/j.hoc.2014.08.008. Epub 2014 Oct 3.
This review discusses the use of prognostic factors, patient and donor selection, choice of conditioning regimens, and timing of transplant. It also describes the management of Philadelphia-positive acute lymphocytic leukemia (ALL) and central nervous system disease. All aggressively treated adults with ALL should be considered for allogeneic transplantation and tissue typed at diagnosis. We further suggest that eligible patients be entered into clinical trials (that incorporate transplantation); these unselected prospective outcome data are essential to evaluate the true value of allogeneic transplantation in adults with ALL.
本综述讨论了预后因素的应用、患者和供体的选择、预处理方案的选择以及移植时机。它还描述了费城染色体阳性急性淋巴细胞白血病（ALL）和中枢神经系统疾病的管理。所有接受积极治疗的成年ALL患者均应考虑进行异基因移植，并在诊断时进行组织分型。我们进一步建议符合条件的患者参加（包含移植的）临床试验；这些未经筛选的前瞻性结果数据对于评估异基因移植在成年ALL患者中的真正价值至关重要。
