Wetzko Katrin, Platzbecker Uwe
Medical Clinic 1, University Hospital "Carl-Gustav-Carus" at TUD, Fetscherstraße 74, 01307 Dresden, Germany.
Medical Clinic 1, University Hospital "Carl-Gustav-Carus" at TUD, Fetscherstraße 74, 01307 Dresden, Germany.
Hematol Oncol Clin North Am. 2014 Dec;28(6):1011-22. doi: 10.1016/j.hoc.2014.08.012. Epub 2014 Sep 29.
Myelodysplastic syndromes are one of the most common hematological disorders in the elderly. Therefore, an increase in the prevalence of de novo but also of secondary forms after prior chemotherapy or radiotherapy, respectively, is anticipated within the next years. Allogeneic stem cell transplantation is considered the only potentially curable therapy, but many patients are not eligible because of age or comorbidities. Reduced-intensity conditioning regimens have improved early tolerability of the procedure, although late effects remain a challenge in the care of these patients. However, hypomethylating agents have become available as alternative therapeutic approaches with a moderate toxicity profile.
骨髓增生异常综合征是老年人中最常见的血液系统疾病之一。因此，预计在未来几年，初发形式以及先前化疗或放疗后继发形式的发病率都会增加。异基因干细胞移植被认为是唯一可能治愈的疗法，但许多患者因年龄或合并症而不符合条件。降低强度的预处理方案改善了该程序的早期耐受性，尽管晚期效应在这些患者的护理中仍然是一个挑战。然而，低甲基化药物已成为具有中度毒性特征的替代治疗方法。
