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伴有贫血和中性粒细胞减少的大颗粒淋巴细胞淋巴细胞增多症：LGL群体单克隆性的证据，但临床病程良性。

Lymphocytosis of large granular lymphocytes associated with anemia and neutropenia: proof of monoclonality of the LGL-population, but benign clinical course.

作者信息

Serke S, Neubauer A, Huhn D

机构信息

Abteilung für Innere Medizin, Universitätsklinikum Rudolf Virchow der Freien Universität Berlin, Standort Charlottenburg.

出版信息

Klin Wochenschr. 1989 Jun 1;67(11):588-91. doi: 10.1007/BF01721686.

DOI:10.1007/BF01721686
PMID:2545968
Abstract

A 37-year-old man with severe transfusion-requiring anemia and neutropenia associated with lymphocytosis of large granular lymphocytes (LGLs) has been followed over a period of 3.5 years. Detailed phenotyping of the LGL has been performed, revealing a phenotype of CD3+, CD8+, CD16+, HLA-DR+, and Leu-7+. Southern-blot analysis of the T-cell receptor beta-chain locus detected a gene rearrangement, thus providing proof of monoclonality of the peripheral blood LGLs.

摘要

一名37岁男性，患有严重的需输血性贫血和中性粒细胞减少症，并伴有大颗粒淋巴细胞（LGL）淋巴细胞增多症，已随访3.5年。对LGL进行了详细的表型分析，结果显示其表型为CD3 +、CD8 +、CD16 +、HLA - DR +和Leu - 7 +。对T细胞受体β链基因座进行Southern印迹分析，检测到基因重排，从而证明外周血LGL具有单克隆性。

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本文引用的文献

1
Large granular lymphocytes: morphological studies.大颗粒淋巴细胞：形态学研究。
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Unusual phenotype and function of an expanded subpopulation of T cells in patients with haemopoietic disorders.造血系统疾病患者中T细胞亚群扩增的异常表型与功能
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Chronic T-cell lymphocytosis with neutropenia: report of a case studied with monoclonal antibody.伴有中性粒细胞减少的慢性T细胞淋巴细胞增多症：一例用单克隆抗体研究的病例报告
Blood. 1981 Oct;58(4):818-22.
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Pure red cell aplasia and hypogammaglobulinemia associated with Tr-cell chronic lymphocytic leukemia.与调节性T细胞慢性淋巴细胞白血病相关的纯红细胞再生障碍和低丙种球蛋白血症。
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Expanded T gamma cell populations with the morphology of large granular lymphocytes -- I. Immunological, clinical and morphological characterization.具有大颗粒淋巴细胞形态的扩增Tγ细胞群体——I. 免疫学、临床及形态学特征
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6
Chronic lymphocytosis with neutropenia: evidence for a novel, abnormal T-cell population associated with antibody-mediated neutrophil destruction.伴有中性粒细胞减少的慢性淋巴细胞增多症：与抗体介导的中性粒细胞破坏相关的新型异常T细胞群体的证据。
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7
Generation of CFU-C/suppressor T cells in vitro: an experimental model for immune-mediated marrow failure.体外生成集落形成单位 - 细胞/抑制性T细胞：免疫介导的骨髓衰竭的实验模型
Blood. 1981 Mar;57(3):491-6.
8
T gamma-lymphoproliferative disease and related disorders in humans and experimental animals: a review of the clinical, cellular, and functional characteristics.人类和实验动物中的Tγ淋巴细胞增殖性疾病及相关病症：临床、细胞及功能特征综述
Blood. 1984 Dec;64(6):1146-58.
9
Characterization of two patients with lymphomas of large granular lymphocytes.两名大颗粒淋巴细胞淋巴瘤患者的特征描述。
Cancer. 1984 Feb 1;53(3):445-52. doi: 10.1002/1097-0142(19840201)53:3<445::aid-cncr2820530313>3.0.co;2-d.
10
Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor.人类大颗粒淋巴细胞（LGL）产生多种淋巴因子的能力：白细胞介素2、干扰素和集落刺激因子。
J Immunol. 1983 Nov;131(5):2379-85.