Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Ames, IA 50010, USA.
Department of Biomedical Sciences, Iowa State University, College of Veterinary Medicine, 2028 Vet Med, Ames, IA 50011, USA.
Int J Antimicrob Agents. 2015 Jan;45(1):76-8. doi: 10.1016/j.ijantimicag.2014.09.011. Epub 2014 Oct 18.
Plazomicin is a next-generation aminoglycoside with a potentially unique set of clinical characteristics compared with other aminoglycosides. This study assessed the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of plazomicin against 15 clinical isolates as well as three reference strains representing Brucella abortus, Brucella melitensis and Brucella suis. These data were compared with those obtained for six other aminoglycosides and two aminocyclitols. Plazomicin and gentamicin were the only drugs demonstrating bactericidal activity towards two of the three Brucella spp., whilst plazomicin was the only drug exhibiting bactericidal activity against B. suis. This is the first study to assess the bactericidal nature of plazomicin against Brucella spp. in vitro.
泊沙康唑是一种新型氨基糖苷类药物，与其他氨基糖苷类药物相比，具有潜在独特的临床特征。本研究评估了 15 株临床分离株以及 3 株代表布鲁氏菌属 abortus、melitensis 和 suis 的参考菌株对泊沙康唑的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。这些数据与另外六种氨基糖苷类药物和两种氨基环醇类药物的数据进行了比较。泊沙康唑和庆大霉素是仅有的两种对三种布鲁氏菌属中的两种显示杀菌活性的药物，而泊沙康唑是唯一对 B. suis 显示杀菌活性的药物。这是首次评估泊沙康唑在体外对布鲁氏菌属的杀菌特性。
