Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada.
Bioproducts and Bioprocesses, Science and Technology Branch, Agriculture and Agri-Food Canada, Government of Canada, Saskatoon Research Centre, 107 Science Place, Saskatoon, SK S7N0X2, Canada.
Bioresour Technol. 2015 Jan;175:517-28. doi: 10.1016/j.biortech.2014.10.130. Epub 2014 Nov 4.
The study presents an ex ante technoeconomic analysis of commercial production of Pseudomonas fluorescens BRG100 bioherbicide in Canada. An engineering economic model is designed in SuperPro Designer® to investigate capital investment scaling and profitability. Total capital investment for a stand-alone BRG100 fermentation plant at baseline capacity (two 33,000L fermenters; 3602tonnesannum(-1)) is $17.55million. Total annual operating cost is $14.76million. Raw materials account for 50% of operating cost. The fermentation plant is profitable over wide operating scale, evaluated over a range of BRG100 prices and costs of capital. Smaller plants require higher NPV breakeven prices. However, larger plants are more sensitive to changes in the cost of capital. Unit production costs decrease as plant capacity increases, indicating scale economies. A plant operating for less than one year approaches positive NPV for periods as low as 2months. These findings can support bioherbicide R&D investment and commercialization strategies.
本研究对 Pseudomonas fluorescens BRG100 生物除草剂在加拿大的商业化生产进行了事前技术经济分析。使用 SuperPro Designer®设计了一个工程经济模型，以研究资本投资规模和盈利能力。在基准产能（两个 33000L 发酵罐；每年 3602 吨）下，独立的 BRG100 发酵工厂的总资本投资为 1755 万美元。总年运营成本为 1476 万美元。原材料占运营成本的 50%。该发酵工厂在广泛的运营规模范围内具有盈利性，在 BRG100 价格和资本成本的范围内进行了评估。较小的工厂需要更高的 NPV 盈亏平衡价格。然而，更大的工厂对资本成本的变化更为敏感。随着工厂产能的增加，单位生产成本下降，表明存在规模经济。对于运营时间少于一年的工厂，只要 2 个月的时间，就可以接近正的 NPV。这些发现可以为生物除草剂的研发投资和商业化策略提供支持。
