Baeza-Velasco Carolina, Pailhez Guillem, Bulbena Antonio, Baghdadli Amaria
Department of Child and Adolescent Psychiatry, CHU Montpellier, France; Institut de Psychologie, Université Paris Descartes, Sorbonne Paris Cité, France.
Anxiety Unit-Institut de Neuropsiquiatria i Addicions (INAD), Hospital del Mar, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Gen Hosp Psychiatry. 2015 Jan-Feb;37(1):24-30. doi: 10.1016/j.genhosppsych.2014.10.002. Epub 2014 Oct 16.
The heritable disorders of connective tissue (HDCTs) are a group of genetic disorders affecting connective tissue matrix proteins. Fragility, laxity of tissues and joint hypermobility (JH) are commons features of HDCT for which the prognosis may range from benign to life threatening. JH and HDCTs, especially joint hypermobility syndrome, Ehlers-Danlos syndromes and Marfan syndrome, have been associated with psychiatric symptomatology. We explored the existing knowledge concerning this association in order to provide an overview of mental disorders linked to JH/HDCT, as well as the hypotheses proposed to explain such association.
A comprehensive search of scientific online databases and references lists was conducted, encompassing publications based on quantitative and qualitative research, including case reports.
Psychiatric conditions in which there is some evidence of an association with JH/HDCT are anxiety disorders, depression, schizophrenia, neurodevelopmental disorders (autism, attention deficit/hyperactivity disorder, and developmental coordination disorder), eating disorders, personality disorders and substance use/misuse.
Despite the need of more research, the available data highlight the importance of examining psychiatric symptoms in those affected by JH/HDCT and the importance of providing interventions with a multidisciplinary approach. The relationship between JH/HDCT and mental disorders merits further attention in order to improve current knowledge and clarify a possible common etiology.
结缔组织遗传性疾病（HDCTs）是一组影响结缔组织基质蛋白的遗传性疾病。组织脆弱、松弛以及关节活动过度（JH）是HDCT的常见特征，其预后范围从良性到危及生命不等。JH与HDCTs，尤其是关节活动过度综合征、埃勒斯-当洛综合征和马凡综合征，已被发现与精神症状有关。我们探究了有关这种关联的现有知识，以便概述与JH/HDCT相关的精神障碍，以及为解释这种关联而提出的假说。
对科学在线数据库和参考文献列表进行了全面检索，涵盖基于定量和定性研究的出版物，包括病例报告。
有一些证据表明与JH/HDCT相关的精神疾病有焦虑症、抑郁症、精神分裂症、神经发育障碍（自闭症、注意力缺陷多动障碍和发育协调障碍）、饮食失调、人格障碍以及物质使用/滥用。
尽管需要更多研究，但现有数据凸显了在受JH/HDCT影响的人群中检查精神症状的重要性，以及采用多学科方法提供干预措施的重要性。JH/HDCT与精神障碍之间的关系值得进一步关注，以便增进当前的认识并阐明可能的共同病因。
